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Secondary parkinsonism+Parkinsonism in other disease


postencephalitic Parkinson disease: Parkinsonism following encephalitis, historically seen as a sequella of encephalitis lethargica (Von Economo Encephalitis). The early age of onset, the rapid progression of symptoms followed by stabilization, and the presence of a variety of other neurological disorders (e.g., sociopathic behavior; TICS; MUSCLE SPASMS; oculogyric crises; hyperphagia; and bizarre movements) distinguish this condition from primary PARKINSON DISEASE. Pathologic features include neuronal loss and gliosis concentrated in the MESENCEPHALON; SUBTHALAMUS; and HYPOTHALAMUS. (From Adams et al., Principles of Neurology, 6th ed, p754)

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Endpoint definition

Endpoint definition steps


Phenotype data


1. Apply sex-specific rule



2. Check conditions



3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G21, G22*, G22*A52.1
  • Hospital discharge: ICD-9 3321
  • Hospital discharge: ICD-8 3420[8-9]
  • Cause of death: ICD-10 G21, G22*, G22*A52.1
  • Cause of death: ICD-9 3321
  • Cause of death: ICD-8 3420[8-9]

2 out of 7 registries used, show all original rules.


4. Check minimum number of events



5. Include endpoints



6. Filter based on genotype QC (FinnGen only)


Control definitions (FinnGen only)

Control exclude G6_XTRAPYR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics


This endpoint is excluded from FinRegistry analyses (omitted endpoint).


Key figures

All Female Male
Number of individuals 807 331 476
Unadjusted period prevalence (%) 0.21 0.14 0.26
Median age at first event (years) 65.11 64.49 65.54


Age distribution of first events


Year distribution of first events


Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: G6_PARKSCND – Secondary parkinsonism+Parkinsonism in other disease

GWS hits: -

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