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Toxic encephalopathy

DOID EFO Endpoint Browser PheWeb

G6_ENCEPHTOX

toxic encephalopathy: A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G92
  • Hospital discharge: ICD-9 — 3498B
  • Hospital discharge: ICD-8 — 32302
  • Cause of death: ICD-10 — G92
  • Cause of death: ICD-9 — 3498B
  • Cause of death: ICD-8 — 32302

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

64

Control definitions (FinnGen only)

Control exclude G6_OTHNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G90-G99
Name in latin Encephalopathia toxica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 830 208 606
Only index persons 579 148 431
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.01 0.01 0.02
Median age at first event (years)
Whole population 54.80 56.22 54.21
Only index persons 54.43 55.16 54.19

-FinnGen-

Key figures

All Female Male
Number of individuals 64 15 49
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 55.61 55.41 55.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: G6_ENCEPHTOX – Toxic encephalopathy

GWS hits: -

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