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Felty syndrome

DOID EFO Endpoint Browser PheWeb

FELTY

Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M05.0
  • Hospital discharge: ICD-9 — 7141
  • Hospital discharge: ICD-8 — 71210
  • Cause of death: ICD-10 — M05.0
  • Cause of death: ICD-9 — 7141
  • Cause of death: ICD-8 — 71210

2 out of 7 registries used, show all original rules.

165

4. Check minimum number of events

None

165

5. Include endpoints

None

165

6. Filter based on genotype QC (FinnGen only)

160

Control definitions (FinnGen only)

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 M05
Name in latin Syndroma Felty

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2047 1446 568
Only index persons 1398 1042 356
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.03 0.04 0.01
Median age at first event (years)
Whole population 66.27 66.71 64.83
Only index persons 62.81 63.27 61.45

-FinnGen-

Key figures

All Female Male
Number of individuals 160 117 43
Unadjusted period prevalence (%) 0.04 0.05 0.02
Median age at first event (years) 59.27 58.47 61.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: FELTY – Felty syndrome

GWS hits: 2

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