Manic episode

F5_MANIA

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F30
  • Cause of death: ICD-10 F30

2 out of 7 registries used, show all original rules.

1047

4. Check minimum number of events

None

1047

5. Include endpoints

None

1047

6. Filter based on genotype QC (FinnGen only)

992

Control definitions (FinnGen only)

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F30-F39
Name in latin Mania

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8563 4317 4191
Only index persons 7736 3974 3762
Unadjusted period prevalence (%)
Whole population 0.12 0.12 0.12
Only index persons 0.14 0.15 0.14
Median age at first event (years)
Whole population 47.10 47.61 46.64
Only index persons 45.55 45.98 45.08

-FinnGen-

Key figures

All Female Male
Number of individuals 992 545 447
Unadjusted period prevalence (%) 0.24 0.24 0.25
Median age at first event (years) 44.03 41.66 46.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: F5_MANIA – Manic episode

GWS hits: -

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