unipolar depression: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
49658 |
4. Check minimum number of eventsNone |
49658 |
5. Include endpoints |
49693 |
6. Filter based on genotype QC (FinnGen only) |
47695 |
Control definitions (FinnGen only)
Control exclude
F5_MOOD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Depression
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 533807 | 324178 | 206012 |
| Only index persons | 482171 | 298790 | 183381 |
| Unadjusted period prevalence (%) | |||
| Whole population | 7.89 | 9.29 | 5.76 |
| Only index persons | 9.47 | 10.98 | 7.00 |
| Median age at first event (years) | |||
| Whole population | 39.47 | 39.23 | 39.79 |
| Only index persons | 37.37 | 37.05 | 37.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 47695 | 32178 | 15517 |
| Unadjusted period prevalence (%) | 12.20 | 13.97 | 8.53 |
| Median age at first event (years) | 41.68 | 39.69 | 45.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: F5_DEPRESSIO – Depression
GWS hits: 23
Loading Relationships table