Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
461 |
4. Check minimum number of eventsNone |
461 |
5. Include endpointsNone |
461 |
6. Filter based on genotype QC (FinnGen only) |
441 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_EXCL
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D72
Name in latin
Eosinophilia
Similar endpoints
↥List of similar endpoints to
Eosinophilic disease (BM)
based on the number of shared cases.
Broader endpoints:
- Eosinophilia
- Other disorders of white blood cells
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Excluding asthma or asthma-COPD overlap
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3527 | 1843 | 1656 |
| Only index persons | 3164 | 1666 | 1498 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 54.37 | 53.72 | 55.30 |
| Only index persons | 53.92 | 52.99 | 54.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 441 | 239 | 202 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.11 |
| Median age at first event (years) | 57.44 | 53.96 | 61.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: ESOSINOPHIL_DISEASE – Eosinophilic disease (BM)
GWS hits: -
Loading Relationships table