Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1607 |
4. Check minimum number of eventsNone |
1607 |
5. Include endpoints |
1701 |
6. Filter based on genotype QC (FinnGen only) |
1614 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D70-D77
Name in latin
Aliae morbositates leucocytorum
Similar endpoints
↥List of similar endpoints to
Other disorders of white blood cells
based on the number of shared cases.
Broader endpoints:
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15172 | 7959 | 7095 |
| Only index persons | 12791 | 6804 | 5987 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.23 | 0.20 |
| Only index persons | 0.24 | 0.25 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 58.28 | 57.40 | 59.16 |
| Only index persons | 56.26 | 54.92 | 57.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1614 | 863 | 751 |
| Unadjusted period prevalence (%) | 0.39 | 0.37 | 0.41 |
| Median age at first event (years) | 56.97 | 52.65 | 61.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits: -
Loading Relationships table