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Thyrotoxicosis with toxic single thyroid nodule

DOID EFO Endpoint Browser PheWeb

E4_THYTOXNOD

Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E05.1
  • Hospital discharge: ICD-9 — 2421
  • Cause of death: ICD-10 — E05.1
  • Cause of death: ICD-9 — 2421

2 out of 7 registries used, show all original rules.

249

4. Check minimum number of events

None

249

5. Include endpoints

None

249

6. Filter based on genotype QC (FinnGen only)

246

Control definitions (FinnGen only)

Control exclude THYROTOXICOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma uninodulari

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2093 1687 393
Only index persons 1884 1532 352
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.01
Only index persons 0.05 0.06 0.01
Median age at first event (years)
Whole population 55.27 53.98 60.60
Only index persons 53.93 52.58 59.83

-FinnGen-

Key figures

All Female Male
Number of individuals 246 204 42
Unadjusted period prevalence (%) 0.08 0.09 0.02
Median age at first event (years) 52.60 49.93 65.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule

GWS hits: 1

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