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Thyrotoxicosis with toxic multinodular goitre

DOID EFO Endpoint Browser PheWeb

E4_THYTOXGOITMULT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E05.2
  • Hospital discharge: ICD-9 — 2422
  • Hospital discharge: ICD-8 — 2421
  • Cause of death: ICD-10 — E05.2
  • Cause of death: ICD-9 — 2422
  • Cause of death: ICD-8 — 2421

2 out of 7 registries used, show all original rules.

1758

4. Check minimum number of events

None

1758

5. Include endpoints

None

1758

6. Filter based on genotype QC (FinnGen only)

1717

Control definitions (FinnGen only)

Control exclude THYROTOXICOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma multinodulari

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18329 15393 2783
Only index persons 14535 12435 2100
Unadjusted period prevalence (%)
Whole population 0.38 0.44 0.08
Only index persons 0.40 0.46 0.08
Median age at first event (years)
Whole population 60.94 60.51 63.51
Only index persons 60.38 59.55 65.30

-FinnGen-

Key figures

All Female Male
Number of individuals 1717 1387 330
Unadjusted period prevalence (%) 0.52 0.60 0.18
Median age at first event (years) 60.35 58.64 67.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre

GWS hits: 16

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