Polycystic ovarian syndrome, consortium definition

E4_PCOS_CONCORTIUM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

only females

239906

2. Check conditions

None

239906

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L68.0#, N92.5, N92.6
  • Hospital discharge: ICD-9 626|7041
  • Hospital discharge: ICD-8 626|70405
  • Hospital discharge: excluded ICD-10 E2839|E24|E23[0-4]|E25|F50|F11|D25|D352|E22|E221|C56|D27|Q96|N643|C74
  • Hospital discharge: excluded ICD-9 2563|25631|2568|2550|2580|2434A|2532[AB]2552|3071A|3072A|3075[AB]|304|2180|253X|2531X|2531A|2395|220|7586|2531A|2270|1940
  • Hospital discharge: excluded ICD-8 2561|255|258|2561|255|3065|304|21899|2262|253|253|183|22099|7595|253|2260
  • Cause of death: ICD-10 L68.0#, N92.5, N92.6
  • Cause of death: ICD-9 626|7041
  • Cause of death: ICD-8 626|70405
  • Cause of death: excluded ICD-10 E2839|E24|E23[0-4]|E25|F50|F11|D25|D352|E22|E221|C56|D27|Q96|N643|C74
  • Cause of death: excluded ICD-9 2563|25631|2568|2550|2580|2434A|2532[AB]2552|3071A|3072A|3075[AB]|304|2180|253X|2531X|2531A|2395|220|7586|2531A|2270|1940
  • Cause of death: excluded ICD-8 2561|255|258|2561|255|3065|304|21899|2262|253|253|183|22099|7595|253|2260

2 out of 7 registries used, show all original rules.

25667

4. Check minimum number of events

None

25667

5. Include endpoints

35716

6. Filter based on genotype QC (FinnGen only)

34386

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6v3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 332746 332746 -
Only index persons 300142 300142 -
Unadjusted period prevalence (%)
Whole population 9.53 9.53 -
Only index persons 11.03 11.03 -
Median age at first event (years)
Whole population - 41.76 -
Only index persons - 40.90 -

-FinnGen-

Key figures

All Female Male
Number of individuals 34386 34386 -
Unadjusted period prevalence (%) 14.93 14.93 -
Median age at first event (years) 39.77 39.77 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: E4_PCOS_CONCORTIUM – Polycystic ovarian syndrome, consortium definition

GWS hits: 4

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