Hypopituitarism

E4_HYPOPIT

hypopituitarism: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09 Hospital discharge: ICD-9 — 2532 Hospital discharge: ICD-8 — 2531 Cause of death: ICD-10 — E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09 Cause of death: ICD-9 — 2532 Cause of death: ICD-8 — 2531 KELA reimbursements: KELA codes — 101 3 out of 7 registries used, show all original rules.	2193
4. Check minimum number of events None	2193
5. Include endpoints None	2193
6. Filter based on genotype QC (FinnGen only)	2114

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

NAME	E4_HYPOPIT
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E230
HD_ICD_9	2532
HD_ICD_8	2531
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E230
COD_ICD_9	2532
COD_ICD_8	2531
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	101
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypopituitarism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	15672	5905	9659
Only index persons	13551	5010	8541
Unadjusted period prevalence (%)
Whole population	0.23	0.17	0.27
Only index persons	0.27	0.18	0.33
Median age at first event (years)
Whole population	41.91	39.45	43.37
Only index persons	42.21	38.87	44.17

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	2114	775	1339
Unadjusted period prevalence (%)	0.59	0.34	0.74
Median age at first event (years)	46.50	42.75	48.67

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Hypopituitarism

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Hypopituitarism (E4_HYPOPIT)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints