≡ Risteys
FR+FG R10

Documentation Changelog GitHub Contact & Feedback

Hypoparathyroidism

DOID EFO Endpoint Browser PheWeb

E4_HYPOPARA

hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E20
  • Hospital discharge: ICD-9 — 2521
  • Hospital discharge: ICD-8 — 2521
  • Cause of death: ICD-10 — E20
  • Cause of death: ICD-9 — 2521
  • Cause of death: ICD-8 — 2521
  • KELA reimbursements: KELA codes — 106
  • Medicine purchases: ATC — H05AA

4 out of 7 registries used, show all original rules.

1060

4. Check minimum number of events

Min. number of events 3
1060

5. Include endpoints

None

1060

6. Filter based on genotype QC (FinnGen only)

1032

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hypoparathyreoidismus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8240 6591 1583
Only index persons 6794 5561 1233
Unadjusted period prevalence (%)
Whole population 0.16 0.19 0.04
Only index persons 0.18 0.20 0.05
Median age at first event (years)
Whole population 60.83 61.53 57.93
Only index persons 60.57 61.51 56.35

-FinnGen-

Key figures

All Female Male
Number of individuals 1032 820 212
Unadjusted period prevalence (%) 0.31 0.36 0.12
Median age at first event (years) 59.21 59.09 59.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Relationships between endpoints

↥

Index endpoint: E4_HYPOPARA – Hypoparathyroidism

GWS hits: 1

loading spinner Loading Relationships table