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Hyperaldosteronism

DOID EFO Endpoint Browser PheWeb

E4_HYPERALDO

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E26
  • Hospital discharge: ICD-9 — 2551
  • Hospital discharge: ICD-8 — 25500
  • Cause of death: ICD-10 — E26
  • Cause of death: ICD-9 — 2551
  • Cause of death: ICD-8 — 25500

2 out of 7 registries used, show all original rules.

776

4. Check minimum number of events

None

776

5. Include endpoints

None

776

6. Filter based on genotype QC (FinnGen only)

744

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperaldosteronismus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5523 2949 2543
Only index persons 5035 2705 2330
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.07
Only index persons 0.09 0.10 0.09
Median age at first event (years)
Whole population 57.31 56.48 58.24
Only index persons 56.72 55.67 57.95

-FinnGen-

Key figures

All Female Male
Number of individuals 744 409 335
Unadjusted period prevalence (%) 0.18 0.18 0.18
Median age at first event (years) 57.05 54.60 60.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_HYPERALDO – Hyperaldosteronism

GWS hits: 2

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