diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5634 |
4. Check minimum number of eventsNone |
5634 |
5. Include endpointsNone |
5634 |
6. Filter based on genotype QC (FinnGen only) |
5490 |
Control definitions (FinnGen only)
Control exclude
E4_DIABETES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes with ophthalmic complications
based on the number of shared cases.
Broader endpoints:
- Type 1 diabetes
- Diabetes mellitus
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 28668 | 12811 | 15679 |
| Only index persons | 25666 | 11624 | 14042 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.37 | 0.44 |
| Only index persons | 0.49 | 0.43 | 0.54 |
| Median age at first event (years) | |||
| Whole population | 40.37 | 39.08 | 41.26 |
| Only index persons | 38.76 | 37.22 | 40.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5490 | 2841 | 2649 |
| Unadjusted period prevalence (%) | 1.34 | 1.23 | 1.46 |
| Median age at first event (years) | 35.42 | 32.82 | 38.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: E4_DM1OPTH – Type 1 diabetes with ophthalmic complications
GWS hits: 38
Loading Relationships table