Type 1 diabetes with ophthalmic complications

E4_DM1OPTH

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

5634

4. Check minimum number of events

None

5634

5. Include endpoints

None

5634

6. Filter based on genotype QC (FinnGen only)

5490

Control definitions (FinnGen only)

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 28668 12811 15679
Only index persons 25666 11624 14042
Unadjusted period prevalence (%)
Whole population 0.40 0.37 0.44
Only index persons 0.49 0.43 0.54
Median age at first event (years)
Whole population 40.37 39.08 41.26
Only index persons 38.76 37.22 40.02

-FinnGen-

Key figures

All Female Male
Number of individuals 5490 2841 2649
Unadjusted period prevalence (%) 1.34 1.23 1.46
Median age at first event (years) 35.42 32.82 38.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: E4_DM1OPTH – Type 1 diabetes with ophthalmic complications

GWS hits: 38

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