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Cushing syndrome

DOID EFO Endpoint Browser PheWeb

E4_CUSHING

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E24
  • Hospital discharge: ICD-9 — 2550|2593
  • Hospital discharge: ICD-8 — 2580
  • Cause of death: ICD-10 — E24
  • Cause of death: ICD-9 — 2550|2593
  • Cause of death: ICD-8 — 2580

2 out of 7 registries used, show all original rules.

337

4. Check minimum number of events

None

337

5. Include endpoints

None

337

6. Filter based on genotype QC (FinnGen only)

326

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 E20-E35
Name in latin Syndroma Cushing

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2517 1702 780
Only index persons 1932 1354 578
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.04 0.05 0.02
Median age at first event (years)
Whole population 52.43 51.81 53.66
Only index persons 48.38 47.55 50.32

-FinnGen-

Key figures

All Female Male
Number of individuals 326 229 97
Unadjusted period prevalence (%) 0.09 0.10 0.05
Median age at first event (years) 50.92 47.27 59.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_CUSHING – Cushing syndrome

GWS hits: 1

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