Other coagulation defects

D3_COAGOTHER

thrombophilia: A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D68 Cause of death: ICD-10 — D68 2 out of 7 registries used, show all original rules.	2191
4. Check minimum number of events None	2191
5. Include endpoints D3_VONVILLEBRAND D3_HEREDFXIDEF D3_HEREDOTHCLOFACTORS D3_HAEMORRHAGCIRGUANTICO D3_ACQCOAFACDEF D3_PRIMTHROMBOPHILIA D3_OTHTHROMBOPHILIA D3_COAGDEFNAS	2233
6. Filter based on genotype QC (FinnGen only)	2154

Control definitions (FinnGen only)

Control exclude D3_COAGDEF_PURPUR_HAEMORRHAGIC

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D65-D69

Name in latin Aliae defectus coagulationis

NAME	D3_COAGOTHER
CONTROL_EXCLUDE	D3_COAGDEF_PURPUR_HAEMORRHAGIC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	D3_VONVILLEBRAND\|D3_HEREDFXIDEF\|D3_HEREDOTHCLOFACTORS\|D3_HAEMORRHAGCIRGUANTICO\|D3_ACQCOAFACDEF\|D3_PRIMTHROMBOPHILIA\|D3_OTHTHROMBOPHILIA\|D3_COAGDEFNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D68
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D68
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other coagulation defects based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	20109	12309	7658
Only index persons	17670	11271	6399
Unadjusted period prevalence (%)
Whole population	0.30	0.35	0.21
Only index persons	0.35	0.41	0.24
Median age at first event (years)
Whole population	47.12	40.21	58.04
Only index persons	45.48	39.12	56.67

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	2154	1449	705
Unadjusted period prevalence (%)	0.55	0.63	0.39
Median age at first event (years)	47.77	41.15	61.38

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Other coagulation defects

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Other coagulation defects (D3_COAGOTHER)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints