Non-small cell lung cancer, squamous (controls excluding all cancers)

C3_NSCLC_SQUAM_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

  • HLP_C3_NSCLC_SQUAM
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C34
  • Cause of death: ICD-9 162
  • Cause of death: ICD-8 162
  • Cancer registry: Topography ICD-O-3 C34
  • Cancer registry: Morphology ICD-O-3 8070
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_NSCLC_SQUAM

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

FinnGen case counts by registry codes:

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Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21794 2866 17935
Only index persons 6675 1588 5087
Unadjusted period prevalence (%)
Whole population 0.47 0.08 0.50
Only index persons 0.16 0.06 0.19
Median age at first event (years)
Whole population 67.38 69.07 67.21
Only index persons 70.90 70.57 71.01

-FinnGen-

Key figures

All Female Male
Number of individuals 1510 175 1335
Unadjusted period prevalence (%) 0.66 0.08 0.73
Median age at first event (years) 71.71 69.18 72.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: C3_NSCLC_SQUAM_EXALLC – Non-small cell lung cancer, squamous (controls excluding all cancers)

GWS hits: 2

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