Leiomyosarcoma (controls excluding all cancers)

C3_LEIOMYOSARCOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C48.3|C49.3|C5421
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 8890
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF8

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2431 1595 793
Only index persons 1350 891 459
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 60.12 57.94 64.38
Only index persons 60.59 57.46 66.66

-FinnGen-

Key figures

All Female Male
Number of individuals 179 125 54
Unadjusted period prevalence (%) 0.05 0.05 0.03
Median age at first event (years) 58.09 55.95 63.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: C3_LEIOMYOSARCOMA_EXALLC – Leiomyosarcoma (controls excluding all cancers)

GWS hits: 1

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