Hepatocellular carcinoma (controls excluding all cancers)

C3_HEPATOCELLU_CARC_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C22.0&
  • Cancer registry: Topography ICD-O-3 C22
  • Cancer registry: Morphology ICD-O-3 817[0-5]
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF8

Similar endpoints

List of similar endpoints to Hepatocellular carcinoma (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

FinnGen case counts by registry codes:

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Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8051 2133 5659
Only index persons 4242 1061 3181
Unadjusted period prevalence (%)
Whole population 0.14 0.06 0.16
Only index persons 0.10 0.04 0.12
Median age at first event (years)
Whole population 71.73 74.61 70.78
Only index persons 72.89 76.49 71.69

-FinnGen-

Key figures

All Female Male
Number of individuals 500 57 443
Unadjusted period prevalence (%) 0.22 0.02 0.24
Median age at first event (years) 72.69 73.27 72.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: C3_HEPATOCELLU_CARC_EXALLC – Hepatocellular carcinoma (controls excluding all cancers)

GWS hits: 2

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