asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersCheck mode of ICD-10 codes: %J450 Registry filters: 2 out of 7 registries used, show all original rules. |
11139 |
4. Check minimum number of eventsNone |
11139 |
5. Include endpointsNone |
11139 |
6. Filter based on genotype QC (FinnGen only) |
10723 |
Control definitions (FinnGen only)
Control exclude
J10_ASTHMA, ASTHMA_EXCL
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Allergic asthma (mode)
based on the number of shared cases.
Broader endpoints:
- Allergic asthma (mode) (more control exclusions)
- Asthma (diagnoses ohter than nonallergic)
- Asthma (more control exclusions)
- Asthma
- Asthma, including avohilmo
Narrower endpoints:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10723 | 7099 | 3624 |
| Unadjusted period prevalence (%) | 2.71 | 3.08 | 1.99 |
| Median age at first event (years) | 37.52 | 36.45 | 39.63 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: ALLERG_ASTHMA – Allergic asthma (mode)
GWS hits: 28
Loading Relationships table