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Viral infections of the central nervous system

DOID EFO Endpoint Browser PheWeb

AB1_VIRAL_CNS

viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A80-A89
  • Hospital discharge: ICD-9 — 04[5-9]|071|06[2-4]
  • Hospital discharge: ICD-8 — 04[0-3]|06[2-5]|071
  • Cause of death: ICD-10 — A80-A89
  • Cause of death: ICD-9 — 04[5-9]|071|06[2-4]
  • Cause of death: ICD-8 — 04[0-3]|06[2-5]|071

2 out of 7 registries used, show all original rules.

2146

4. Check minimum number of events

None

2146

5. Include endpoints

2434

6. Filter based on genotype QC (FinnGen only)

2332

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26420 13206 13059
Only index persons 23392 11811 11581
Unadjusted period prevalence (%)
Whole population 0.37 0.38 0.36
Only index persons 0.44 0.43 0.44
Median age at first event (years)
Whole population 31.76 34.52 28.71
Only index persons 30.31 33.40 27.16

-FinnGen-

Key figures

All Female Male
Number of individuals 2332 1393 939
Unadjusted period prevalence (%) 0.57 0.60 0.52
Median age at first event (years) 36.44 34.31 39.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: AB1_VIRAL_CNS – Viral infections of the central nervous system

GWS hits: -

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