Septal defects

Q17_SEPTA_DEFEC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q21.0, Q21.10, Q21.11, Q21.12, Q21.13, Q21.18, Q21.19, Q21.88, Q21.9
  • Hospital discharge: ICD-9 7454E|7454X|7454A|7455A|7456X|7456A|7458X|7459X
  • Hospital discharge: excluded ICD-10 Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Hospital discharge: excluded ICD-9 758|7595|75683
  • Cause of death: ICD-10 Q21.0, Q21.10, Q21.11, Q21.12, Q21.13, Q21.18, Q21.19, Q21.88, Q21.9
  • Cause of death: ICD-9 7454E|7454X|7454A|7455A|7456X|7456A|7458X|7459X
  • Cause of death: excluded ICD-10 Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Cause of death: excluded ICD-9 758|7595|75683

2 out of 7 registries used, show all original rules.

2034

4. Check minimum number of events

None

2034

5. Include endpoints

None

2034

6. Filter based on genotype QC (FinnGen only)

1950

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37758 20128 17561
Only index persons 24425 13039 11386
Unadjusted period prevalence (%)
Whole population 0.54 0.58 0.49
Only index persons 0.46 0.48 0.43
Median age at first event (years)
Whole population 0.53 0.50 0.42
Only index persons 3.90 4.73 2.96

-FinnGen-

Key figures

All Female Male
Number of individuals 1950 1158 792
Unadjusted period prevalence (%) 0.48 0.50 0.44
Median age at first event (years) 38.56 35.30 43.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: Q17_SEPTA_DEFEC – Septal defects

GWS hits: 5

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