Pre-eclampsia superimposed on chronic hypertension

O15_PREECLAMPS_CHRONIC_HYPERT

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

only females

239906

2. Check conditions

None

239906

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O11
  • Cause of death: ICD-10 O11

2 out of 7 registries used, show all original rules.

168

4. Check minimum number of events

None

168

5. Include endpoints

None

168

6. Filter based on genotype QC (FinnGen only)

164

Control definitions (FinnGen only)

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O10-O16
Name in latin Hypertensio prae-existens cum proteinuria superposita

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1336 1336 -
Only index persons 1325 1325 -
Unadjusted period prevalence (%)
Whole population 0.04 0.04 -
Only index persons 0.05 0.05 -
Median age at first event (years)
Whole population - 32.55 -
Only index persons - 32.55 -

-FinnGen-

Key figures

All Female Male
Number of individuals 164 164 -
Unadjusted period prevalence (%) 0.07 0.07 -
Median age at first event (years) 33.18 33.18 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: O15_PREECLAMPS_CHRONIC_HYPERT – Pre-eclampsia superimposed on chronic hypertension

GWS hits: -

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