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Pre-eclampsia

DOID EFO Endpoint Browser PheWeb

O15_PREECLAMPS

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

only females

239906

2. Check conditions

None

239906

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O14
  • Hospital discharge: ICD-9 — 642[4-5]
  • Hospital discharge: ICD-8 — 6370[349]
  • Cause of death: ICD-10 — O14
  • Cause of death: ICD-9 — 642[4-5]
  • Cause of death: ICD-8 — 6370[349]

2 out of 7 registries used, show all original rules.

7612

4. Check minimum number of events

None

7612

5. Include endpoints

None

7612

6. Filter based on genotype QC (FinnGen only)

7377

Control definitions (FinnGen only)

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O10-O16
Name in latin Hypertensio gestationalis cum proteinuria significanti

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 64134 64134 -
Only index persons 62521 62521 -
Unadjusted period prevalence (%)
Whole population 1.84 1.84 -
Only index persons 2.30 2.30 -
Median age at first event (years)
Whole population - 28.58 -
Only index persons - 28.55 -

-FinnGen-

Key figures

All Female Male
Number of individuals 7377 7377 -
Unadjusted period prevalence (%) 3.20 3.20 -
Median age at first event (years) 28.72 28.72 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: O15_PREECLAMPS – Pre-eclampsia

GWS hits: 3

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