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Nephrotic syndrome

DOID EFO Endpoint Browser PheWeb

N14_NEPHROTICSYND

nephrotic syndrome: A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N04#
  • Hospital discharge: ICD-9 — 581
  • Hospital discharge: ICD-8 — 581
  • Cause of death: ICD-10 — N04#
  • Cause of death: ICD-9 — 581
  • Cause of death: ICD-8 — 581

2 out of 7 registries used, show all original rules.

964

4. Check minimum number of events

None

964

5. Include endpoints

None

964

6. Filter based on genotype QC (FinnGen only)

917

Control definitions (FinnGen only)

Control exclude N14_GLOMERULAR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N00-N08
Name in latin Syndroma nephroticum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7991 3363 4520
Only index persons 6080 2628 3452
Unadjusted period prevalence (%)
Whole population 0.11 0.10 0.13
Only index persons 0.12 0.10 0.13
Median age at first event (years)
Whole population 50.10 49.08 50.66
Only index persons 45.52 43.36 47.16

-FinnGen-

Key figures

All Female Male
Number of individuals 917 384 533
Unadjusted period prevalence (%) 0.24 0.17 0.29
Median age at first event (years) 47.77 40.10 53.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: N14_NEPHROTICSYND – Nephrotic syndrome

GWS hits: 2

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