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Other intervertebral disc disorders

DOID EFO Endpoint Browser PheWeb

M13_INTERVERTEB

lumbar disc degeneration: Any disease of a degenerative nature that affects the intervertebral disc.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M51
  • Hospital discharge: ICD-9 — 722
  • Hospital discharge: ICD-8 — 725
  • Hospital discharge: excluded ICD-9 — 7220|7224|7227|7228A
  • Hospital discharge: excluded ICD-8 — 7250
  • Cause of death: ICD-10 — M51
  • Cause of death: ICD-9 — 722
  • Cause of death: ICD-8 — 725
  • Cause of death: excluded ICD-9 — 7220|7224|7227|7228A
  • Cause of death: excluded ICD-8 — 7250

2 out of 7 registries used, show all original rules.

43014

4. Check minimum number of events

None

43014

5. Include endpoints

None

43014

6. Filter based on genotype QC (FinnGen only)

41669

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M50-M54
Name in latin Aliae morbositates discorum intervertebralium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 361216 182083 177156
Only index persons 337293 173994 163299
Unadjusted period prevalence (%)
Whole population 5.07 5.22 4.95
Only index persons 6.32 6.40 6.23
Median age at first event (years)
Whole population 48.22 49.60 46.80
Only index persons 47.83 49.27 46.30

-FinnGen-

Key figures

All Female Male
Number of individuals 41669 23517 18152
Unadjusted period prevalence (%) 10.11 10.21 9.98
Median age at first event (years) 49.44 48.91 50.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_INTERVERTEB – Other intervertebral disc disorders

GWS hits: 40

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