Other and unspecified skin changes due to chronic exposure to nonionizing radiation

L12_NONIONRADISKINNAS

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L57.8, L57.9
  • Hospital discharge: ICD-9 7093C
  • Cause of death: ICD-10 L57.8, L57.9
  • Cause of death: ICD-9 7093C

2 out of 7 registries used, show all original rules.

389

4. Check minimum number of events

None

389

5. Include endpoints

None

389

6. Filter based on genotype QC (FinnGen only)

376

Control definitions (FinnGen only)

Control exclude L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3420 1992 1406
Only index persons 3066 1831 1235
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.06 0.07 0.05
Median age at first event (years)
Whole population 71.86 71.91 71.77
Only index persons 71.03 71.15 70.86

-FinnGen-

Key figures

All Female Male
Number of individuals 376 190 186
Unadjusted period prevalence (%) 0.09 0.08 0.10
Median age at first event (years) 67.21 64.65 69.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: L12_NONIONRADISKINNAS – Other and unspecified skin changes due to chronic exposure to nonionizing radiation

GWS hits: 1

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