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Localized scleroderma [morphea]

DOID EFO Endpoint Browser PheWeb

L12_LOCALSCLERODERMA

localised scleroderma: Localized scleroderma is the skin localized form of scleroderma (see this term) characterized by fibrosis of the skin causing cutaneous plaques or strips.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L94.0
  • Hospital discharge: ICD-9 — 7010A
  • Hospital discharge: ICD-8 — 70100
  • Cause of death: ICD-10 — L94.0
  • Cause of death: ICD-9 — 7010A
  • Cause of death: ICD-8 — 70100

2 out of 7 registries used, show all original rules.

411

4. Check minimum number of events

None

411

5. Include endpoints

None

411

6. Filter based on genotype QC (FinnGen only)

394

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L94
Name in latin Scleroderma circumscriptum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3160 2461 682
Only index persons 2953 2322 631
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.02
Only index persons 0.07 0.09 0.02
Median age at first event (years)
Whole population 52.33 54.73 43.53
Only index persons 51.81 54.19 43.06

-FinnGen-

Key figures

All Female Male
Number of individuals 394 322 72
Unadjusted period prevalence (%) 0.12 0.14 0.04
Median age at first event (years) 54.97 55.59 52.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: L12_LOCALSCLERODERMA – Localized scleroderma [morphea]

GWS hits: -

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