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Hypertrophic scar

DOID EFO Endpoint Browser PheWeb

L12_HYPETROPHICSCAR

osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L91.0
  • Hospital discharge: ICD-9 — 7014B
  • Hospital discharge: ICD-8 — 70130
  • Cause of death: ICD-10 — L91.0
  • Cause of death: ICD-9 — 7014B
  • Cause of death: ICD-8 — 70130

2 out of 7 registries used, show all original rules.

1719

4. Check minimum number of events

None

1719

5. Include endpoints

None

1719

6. Filter based on genotype QC (FinnGen only)

1641

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L91
Name in latin Cicatrix cheloides

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16484 10557 5801
Only index persons 15658 10196 5462
Unadjusted period prevalence (%)
Whole population 0.25 0.30 0.16
Only index persons 0.32 0.37 0.21
Median age at first event (years)
Whole population 30.18 31.04 28.53
Only index persons 29.89 30.87 28.06

-FinnGen-

Key figures

All Female Male
Number of individuals 1641 1200 441
Unadjusted period prevalence (%) 0.45 0.52 0.24
Median age at first event (years) 39.34 37.30 44.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: L12_HYPETROPHICSCAR – Hypertrophic scar

GWS hits: 4

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