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Erythema multiforme

DOID EFO Endpoint Browser PheWeb

L12_ERYTHEMAMULTIF

erythema multiforme: Erythema multiforme (EM) refers to a group ofhypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus , suggesting an immunologic process initiated by the virus. In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics. In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome . The most severe of the three is toxic epidermal necrolysis (TEN).

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L51
  • Hospital discharge: ICD-9 — 6951A|6951B|6951C
  • Hospital discharge: ICD-8 — 69510
  • Cause of death: ICD-10 — L51
  • Cause of death: ICD-9 — 6951A|6951B|6951C
  • Cause of death: ICD-8 — 69510

2 out of 7 registries used, show all original rules.

687

4. Check minimum number of events

None

687

5. Include endpoints

None

687

6. Filter based on genotype QC (FinnGen only)

668

Control definitions (FinnGen only)

Control exclude L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L50-L54
Name in latin Erythema multiforme

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7231 3832 3367
Only index persons 6249 3374 2875
Unadjusted period prevalence (%)
Whole population 0.10 0.11 0.09
Only index persons 0.12 0.12 0.11
Median age at first event (years)
Whole population 43.65 47.82 38.77
Only index persons 42.72 46.91 37.82

-FinnGen-

Key figures

All Female Male
Number of individuals 668 409 259
Unadjusted period prevalence (%) 0.16 0.18 0.14
Median age at first event (years) 48.30 45.28 53.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: L12_ERYTHEMAMULTIF – Erythema multiforme

GWS hits: -

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