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Irritable bowel syndrome

DOID EFO Endpoint Browser PheWeb

K11_IBS

irritable bowel syndrome: Gastrointestinal symptoms characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K58
  • Hospital discharge: ICD-9 — 5641
  • Hospital discharge: ICD-8 — 56419
  • Cause of death: ICD-10 — K58
  • Cause of death: ICD-9 — 5641
  • Cause of death: ICD-8 — 56419

2 out of 7 registries used, show all original rules.

10705

4. Check minimum number of events

None

10705

5. Include endpoints

None

10705

6. Filter based on genotype QC (FinnGen only)

10329

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K55-K63
Name in latin Syndroma intestini irritabilis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 86289 59691 26108
Only index persons 80007 56165 23842
Unadjusted period prevalence (%)
Whole population 1.41 1.71 0.73
Only index persons 1.72 2.06 0.91
Median age at first event (years)
Whole population 48.52 49.46 46.36
Only index persons 47.41 48.38 45.12

-FinnGen-

Key figures

All Female Male
Number of individuals 10329 7632 2697
Unadjusted period prevalence (%) 2.84 3.31 1.48
Median age at first event (years) 49.46 48.38 52.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: K11_IBS – Irritable bowel syndrome

GWS hits: -

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