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Hypersensitivity pneumonitis due to organic dust

DOID EFO Endpoint Browser PheWeb

J10_HYPERSPNEUMONI

extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J67
  • Hospital discharge: ICD-9 — 495
  • Cause of death: ICD-10 — J67
  • Cause of death: ICD-9 — 495

2 out of 7 registries used, show all original rules.

485

4. Check minimum number of events

None

485

5. Include endpoints

None

485

6. Filter based on genotype QC (FinnGen only)

476

Control definitions (FinnGen only)

Control exclude J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J60-J70
Name in latin Pneumonitis/alveolitis hypersensitiva e pulvere organico

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5824 2873 2887
Only index persons 4602 2341 2261
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.08
Only index persons 0.09 0.09 0.09
Median age at first event (years)
Whole population 52.93 53.15 52.37
Only index persons 49.96 50.96 48.92

-FinnGen-

Key figures

All Female Male
Number of individuals 476 246 230
Unadjusted period prevalence (%) 0.12 0.11 0.13
Median age at first event (years) 48.56 46.70 50.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust

GWS hits: 1

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