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Thromboangiitis obliterans

DOID EFO Endpoint Browser PheWeb

I9_THROMBANG

thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I73.1
  • Hospital discharge: ICD-9 — 4431A
  • Hospital discharge: ICD-8 — 44310
  • Cause of death: ICD-10 — I73.1
  • Cause of death: ICD-9 — 4431A
  • Cause of death: ICD-8 — 44310

2 out of 7 registries used, show all original rules.

117

4. Check minimum number of events

None

117

5. Include endpoints

None

117

6. Filter based on genotype QC (FinnGen only)

114

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I73
Name in latin Tromboangi(i)tis obliterans (Bürger)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1319 389 900
Only index persons 869 322 547
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.03
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 52.80 53.06 52.44
Only index persons 51.00 51.70 50.59

-FinnGen-

Key figures

All Female Male
Number of individuals 114 40 74
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 49.40 46.15 51.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_THROMBANG – Thromboangiitis obliterans

GWS hits: -

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