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Hypertension, Pulmonary Arterial

DOID EFO Endpoint Browser PheWeb

I9_HYPTENSPUL

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I27.0
  • Hospital discharge: ICD-9 — 4160A
  • Hospital discharge: ICD-8 — 42600
  • Cause of death: ICD-10 — I27.0
  • Cause of death: ICD-9 — 4160A
  • Cause of death: ICD-8 — 42600

2 out of 7 registries used, show all original rules.

261

4. Check minimum number of events

None

261

5. Include endpoints

None

261

6. Filter based on genotype QC (FinnGen only)

248

Control definitions (FinnGen only)

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I27
Name in latin Hypertensio pulmonalis primaria

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2950 1579 1316
Only index persons 1759 1100 659
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 65.26 67.03 63.32
Only index persons 68.00 69.52 65.46

-FinnGen-

Key figures

All Female Male
Number of individuals 248 163 85
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 59.94 58.20 63.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_HYPTENSPUL – Hypertension, Pulmonary Arterial

GWS hits: -

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