Ménière disease

H8_MENIERE

endolymphatic hydrops: An accumulation of endolymph in the inner ear (labyrinth) leading to buildup of pressure and distortion of intralabyrinthine structures, such as cochlea and semicircular canals. It is characterized by sensorineural hearing loss; tinnitus; and sometimes vertigo.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H81.0
  • Hospital discharge: ICD-9 3860
  • Hospital discharge: ICD-8 38599
  • Cause of death: ICD-10 H81.0
  • Cause of death: ICD-9 3860
  • Cause of death: ICD-8 38599

2 out of 7 registries used, show all original rules.

3064

4. Check minimum number of events

None

3064

5. Include endpoints

None

3064

6. Filter based on genotype QC (FinnGen only)

2977

Control definitions (FinnGen only)

Control exclude H8_INNER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H81
Name in latin Morbus Ménière

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26706 17134 9455
Only index persons 24436 15945 8491
Unadjusted period prevalence (%)
Whole population 0.41 0.49 0.26
Only index persons 0.50 0.59 0.32
Median age at first event (years)
Whole population 57.15 57.45 56.61
Only index persons 56.64 56.87 56.19

-FinnGen-

Key figures

All Female Male
Number of individuals 2977 1923 1054
Unadjusted period prevalence (%) 0.74 0.84 0.58
Median age at first event (years) 55.60 54.55 57.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: H8_MENIERE – Ménière disease

GWS hits: 2

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