amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
51 |
4. Check minimum number of eventsNone |
51 |
5. Include endpointsNone |
51 |
6. Filter based on genotype QC (FinnGen only) |
50 |
Control definitions (FinnGen only)
Control exclude
G6_NEUATR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G12
Name in latin
Alia atrophia musculorum spinalis congenita
Similar endpoints
↥List of similar endpoints to
Other inherited muscular atrophy
based on the number of shared cases.
Broader endpoints:
- Systemic atrophies primarily affecting the central nervous system
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 493 | 224 | 266 |
| Only index persons | 366 | 165 | 201 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.54 | 53.40 | 55.54 |
| Only index persons | 52.81 | 50.63 | 54.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 50 | 22 | 28 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 51.15 | 47.34 | 54.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: G6_OTHINMUSC – Other inherited muscular atrophy
GWS hits: -
Loading Relationships table