This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
G6_HUNTINGTON
obsolete_Huntington's disease: ['A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea.', 'A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)']
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
35 |
4. Check minimum number of eventsNone |
35 |
5. Include endpointsNone |
35 |
6. Filter based on genotype QC (FinnGen only) |
33 |
Control definitions (FinnGen only)
Extra metadata
List of similar endpoints to Huntington disease based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
None
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 576 | 300 | 267 |
Only index persons | 422 | 230 | 192 |
Unadjusted period prevalence (%) | |||
Whole population | 0.01 | 0.01 | 0.01 |
Only index persons | 0.01 | 0.01 | 0.01 |
Median age at first event (years) | |||
Whole population | 57.44 | 57.08 | 57.37 |
Only index persons | 56.47 | 56.80 | 56.07 |
All | Female | Male | |
---|---|---|---|
Number of individuals | 33 | 18 | 15 |
Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
Median age at first event (years) | 58.33 | 56.63 | 60.37 |
Not a core endpoint, no data to show.
Index endpoint: G6_HUNTINGTON – Huntington disease
GWS hits: -
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