Causalgia

G6_CAUSALGIA

causalgia: Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia , not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G56.4
  • Hospital discharge: ICD-9 3544
  • Cause of death: ICD-10 G56.4
  • Cause of death: ICD-9 3544

2 out of 7 registries used, show all original rules.

503

4. Check minimum number of events

None

503

5. Include endpoints

None

503

6. Filter based on genotype QC (FinnGen only)

487

Control definitions (FinnGen only)

Control exclude G6_NERPLEX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G56
Name in latin Causalgia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4108 2491 1591
Only index persons 3917 2418 1499
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.04
Only index persons 0.08 0.09 0.06
Median age at first event (years)
Whole population 47.72 47.94 47.37
Only index persons 47.48 47.68 47.16

-FinnGen-

Key figures

All Female Male
Number of individuals 487 343 144
Unadjusted period prevalence (%) 0.13 0.15 0.08
Median age at first event (years) 46.48 45.99 47.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: G6_CAUSALGIA – Causalgia

GWS hits: -

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