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Motor neuron disease

DOID EFO Endpoint Browser PheWeb

G6_ALS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G12.2
  • Hospital discharge: ICD-9 — 3352A
  • Hospital discharge: ICD-8 — 348[0-1]|34821
  • Cause of death: ICD-10 — G12.2
  • Cause of death: ICD-9 — 3352A
  • Cause of death: ICD-8 — 348[0-1]|34821

2 out of 7 registries used, show all original rules.

545

4. Check minimum number of events

None

545

5. Include endpoints

None

545

6. Filter based on genotype QC (FinnGen only)

531

Control definitions (FinnGen only)

Control exclude F5_PSYCH, NEURODIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G12
Name in latin Morbus motoneuronalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8362 3928 4249
Only index persons 4490 2114 2376
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.12
Only index persons 0.08 0.08 0.09
Median age at first event (years)
Whole population 66.30 67.33 65.35
Only index persons 67.14 68.36 66.06

-FinnGen-

Key figures

All Female Male
Number of individuals 531 204 327
Unadjusted period prevalence (%) 0.14 0.09 0.18
Median age at first event (years) 67.38 67.44 67.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: G6_ALS – Motor neuron disease

GWS hits: 4

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