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Vitamin A deficiency

DOID EFO Endpoint Browser PheWeb

E4_VIT_A_DEF

ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E50
  • Hospital discharge: ICD-9 — 264
  • Hospital discharge: ICD-8 — 260
  • Cause of death: ICD-10 — E50
  • Cause of death: ICD-9 — 264
  • Cause of death: ICD-8 — 260

2 out of 7 registries used, show all original rules.

137

4. Check minimum number of events

None

137

5. Include endpoints

None

137

6. Filter based on genotype QC (FinnGen only)

129

Control definitions (FinnGen only)

Control exclude E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E50-E64
Name in latin Deficientia vitamini A

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1746 1131 591
Only index persons 1302 892 410
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 65.53 63.81 68.82
Only index persons 58.80 56.29 64.25

-FinnGen-

Key figures

All Female Male
Number of individuals 129 87 42
Unadjusted period prevalence (%) 0.03 0.04 0.02
Median age at first event (years) 51.99 43.74 69.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_VIT_A_DEF – Vitamin A deficiency

GWS hits: -

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