obsolete_familial combined hyperlipidemia: ['A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1224 |
4. Check minimum number of eventsNone |
1224 |
5. Include endpointsNone |
1224 |
6. Filter based on genotype QC (FinnGen only) |
1184 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E78
Similar endpoints
↥List of similar endpoints to
Mixed hyperlipidaemia
based on the number of shared cases.
Broader endpoints:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9795 | 3468 | 6263 |
| Only index persons | 8546 | 3081 | 5465 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.10 | 0.17 |
| Only index persons | 0.17 | 0.11 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 57.21 | 62.08 | 54.43 |
| Only index persons | 56.64 | 61.35 | 53.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1184 | 410 | 774 |
| Unadjusted period prevalence (%) | 0.34 | 0.18 | 0.43 |
| Median age at first event (years) | 56.02 | 57.22 | 55.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: E4_HYPERLIPMIX – Mixed hyperlipidaemia
GWS hits: 6
Loading Relationships table