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Amyloidosis, other/unspecified

DOID EFO Endpoint Browser PheWeb

E4_AMYLNAS

amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E85[8-9]
  • Hospital discharge: ICD-9 — 2773
  • Hospital discharge: ICD-8 — 27699
  • Cause of death: ICD-10 — E85[8-9]
  • Cause of death: ICD-9 — 2773
  • Cause of death: ICD-8 — 27699

2 out of 7 registries used, show all original rules.

457

4. Check minimum number of events

None

457

5. Include endpoints

None

457

6. Filter based on genotype QC (FinnGen only)

448

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5263 2849 2321
Only index persons 3048 1579 1469
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.06
Only index persons 0.06 0.06 0.06
Median age at first event (years)
Whole population 67.37 66.72 68.27
Only index persons 68.90 67.88 69.99

-FinnGen-

Key figures

All Female Male
Number of individuals 448 221 227
Unadjusted period prevalence (%) 0.11 0.10 0.12
Median age at first event (years) 65.85 60.94 70.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_AMYLNAS – Amyloidosis, other/unspecified

GWS hits: 10

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