Certain disorders involving the immune mechanism

D3_IMMUNEMECHANISM

immune system disease: A disorder resulting from an abnormality in the immune system.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints D3_IMMUDEFANTIBODY D3_COMBIMMUDEF D3_IMMUDEFWITHMAJORDEF D3_CVID D3_IMMUDEFOTHER D3_KELA_IMMUDEF D3_SARCOIDOSIS D3_IMMUNEMECHANISMOTHER	6805
6. Filter based on genotype QC (FinnGen only)	6561

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	D3_IMMUNEMECHANISM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	D3_IMMUDEFANTIBODY\|D3_COMBIMMUDEF\|D3_IMMUDEFWITHMAJORDEF\|D3_CVID\|D3_IMMUDEFOTHER\|D3_KELA_IMMUDEF\|D3_SARCOIDOSIS\|D3_IMMUNEMECHANISMOTHER
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Certain disorders involving the immune mechanism based on the number of shared cases.

Broader endpoints:

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	50702	26913	23461
Only index persons	44339	23677	20662
Unadjusted period prevalence (%)
Whole population	0.71	0.77	0.66
Only index persons	0.83	0.87	0.79
Median age at first event (years)
Whole population	46.66	49.29	43.59
Only index persons	45.47	47.89	42.69

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	6561	3633	2928
Unadjusted period prevalence (%)	1.59	1.58	1.61
Median age at first event (years)	47.05	47.33	46.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: D3_IMMUNEMECHANISM – Certain disorders involving the immune mechanism

GWS hits: 10

Loading Relationships table

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Certain disorders involving the immune mechanism

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints