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Later onset COPD

DOID Endpoint Browser PheWeb

COPD_LATER

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • not COPD_EARLY
421297

3. Check pre-conditions, main-only, mode, registry filters

Pre-conditions: EVENT_AGE>=65

Registry filters:

  • Hospital discharge: ICD-10 — J44
  • Hospital discharge: ICD-9 — 4912
  • Hospital discharge: ICD-8 — 49104
  • Cause of death: ICD-10 — J44
  • Cause of death: ICD-9 — 4912
  • Cause of death: ICD-8 — 49104

2 out of 7 registries used, show all original rules.

11824

4. Check minimum number of events

None

11824

5. Include endpoints

None

11824

6. Filter based on genotype QC (FinnGen only)

11519

Control definitions (FinnGen only)

Control exclude COPD_EARLYANDLATER
Control pre-conditions DEATH_AGE>=65
Control conditions not COPD_EARLY

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Alii morbi obstructivi chronici pulmonum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 11519 2014 9505
Unadjusted period prevalence (%) 4.47 0.87 5.23
Median age at first event (years) 73.41 71.93 73.72

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: COPD_LATER – Later onset COPD

GWS hits: 3

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