Osteosarcoma (controls excluding all cancers)

C3_OSTEOSARCOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C40.1|C4103|C4107|C4113|C4121|C4131|C4141|C4181|C4191
  • Cancer registry: Topography ICD-O-3 C4[0-1]
  • Cancer registry: Morphology ICD-O-3 9180|9181|9183|9200|9261
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF8

Case counts by codes

FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 717 278 426
Only index persons 401 168 233
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 21.08 19.75 21.26
Only index persons 19.42 17.67 20.68

-FinnGen-

Key figures

All Female Male
Number of individuals 64 26 38
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 24.18 16.72 29.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: C3_OSTEOSARCOMA_EXALLC – Osteosarcoma (controls excluding all cancers)

GWS hits: -

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