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Chronic lymphocytic leukaemia (controls excluding all cancers)

Endpoint Browser PheWeb

C3_CLL_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_CLL
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C91.1
  • Cause of death: ICD-9 — 2041A
  • Cause of death: ICD-8 — 20415
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 9823
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_CLL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8468 3276 5047
Only index persons 5092 2091 3001
Unadjusted period prevalence (%)
Whole population 0.12 0.09 0.14
Only index persons 0.10 0.08 0.11
Median age at first event (years)
Whole population 69.99 71.38 69.13
Only index persons 69.99 70.88 69.36

-FinnGen-

Key figures

All Female Male
Number of individuals 668 208 460
Unadjusted period prevalence (%) 0.20 0.09 0.25
Median age at first event (years) 68.12 67.34 68.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: C3_CLL_EXALLC – Chronic lymphocytic leukaemia (controls excluding all cancers)

GWS hits: 5

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