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Acute myeloid leukaemia (controls excluding all cancers)

Endpoint Browser PheWeb

C3_AML_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_AML
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C92.0
  • Cause of death: ICD-9 — 2050A
  • Cause of death: ICD-8 — 20500
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 9840|9861|986[67]|987[1-4]|989[1567]|9910|9920|993[01]
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_AML

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6001 2847 2999
Only index persons 2621 1336 1285
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.08
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 65.21 64.86 65.46
Only index persons 66.44 65.75 67.16

-FinnGen-

Key figures

All Female Male
Number of individuals 244 94 150
Unadjusted period prevalence (%) 0.07 0.04 0.08
Median age at first event (years) 65.50 56.91 70.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: C3_AML_EXALLC – Acute myeloid leukaemia (controls excluding all cancers)

GWS hits: -

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