Acute lymphocytic leukaemia (controls excluding all cancers)

C3_ALL_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

  • HLP_C3_ALL
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C91.0
  • Cause of death: ICD-9 2040A
  • Cause of death: ICD-8 20400
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 981[1-8]|9835
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_ALL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

FinnGen case counts by registry codes:

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Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3167 1432 1713
Only index persons 1750 850 900
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.05
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 11.29 9.66 12.08
Only index persons 8.20 7.38 8.98

-FinnGen-

Key figures

All Female Male
Number of individuals 197 112 85
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 8.53 6.21 11.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: C3_ALL_EXALLC – Acute lymphocytic leukaemia (controls excluding all cancers)

GWS hits: -

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