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Atopic dermatitis, strict definition

DOID Endpoint Browser

ATOPIC_STRICT

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L20.0
  • Hospital discharge: ICD-9 — 6918B
  • Hospital discharge: ICD-8 — 69100
  • Cause of death: ICD-10 — L20.0
  • Cause of death: ICD-9 — 6918B
  • Cause of death: ICD-8 — 69100

2 out of 7 registries used, show all original rules.

11904

4. Check minimum number of events

None

11904

5. Include endpoints

None

11904

6. Filter based on genotype QC (FinnGen only)

11509

Control definitions (FinnGen only)

Control exclude ATOPIC_STRICT_REIMB

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 L20
Name in latin Eczema atopicum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 11509 8144 3365
Unadjusted period prevalence (%) 3.04 3.54 1.85
Median age at first event (years) 23.36 24.42 20.78

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: ATOPIC_STRICT – Atopic dermatitis, strict definition

GWS hits: -

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