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Infections with a predominantly sexual mode of transmission

DOID EFO Endpoint Browser PheWeb

AB1_SEXUAL_TRANSMISSION

tabes dorsalis: A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A50-A64
  • Hospital discharge: ICD-9 — 09[0-9]|0541|131|0781C
  • Hospital discharge: ICD-8 — 09[0-9]|131
  • Cause of death: ICD-10 — A50-A64
  • Cause of death: ICD-9 — 09[0-9]|0541|131|0781C
  • Cause of death: ICD-8 — 09[0-9]|131

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

12557

6. Filter based on genotype QC (FinnGen only)

11984

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 123298 78020 44342
Only index persons 117330 75050 42280
Unadjusted period prevalence (%)
Whole population 1.87 2.23 1.24
Only index persons 2.35 2.76 1.61
Median age at first event (years)
Whole population 26.14 25.54 27.09
Only index persons 25.93 25.40 26.88

-FinnGen-

Key figures

All Female Male
Number of individuals 11984 8892 3092
Unadjusted period prevalence (%) 3.30 3.86 1.70
Median age at first event (years) 27.91 26.59 31.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: AB1_SEXUAL_TRANSMISSION – Infections with a predominantly sexual mode of transmission

GWS hits: -

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